The Texas Panhandle gets its name for its proximity to the handle-shaped portion of its neighbor, Oklahoma. It is the state's least populated region. Hemphill County ranks 252nd in Texas for the total number of acres of land currently advertised for sale. New Mobeetie featured the most land for sale. Mining and mineral extraction-related services are the main economic drivers in this part of Texas. Hemphill County is Texas's 142nd largest county (912 square miles). It's located in the Panhandle Texas region of Texas.