The Texas Panhandle gets its name for its proximity to the handle-shaped portion of its neighbor, Oklahoma. It is the state's least populated region. Hemphill County ranks 251st out of 254 counties in the Lone Star State for the total acreage of land currently advertised for sale. Canadian had the most land for sale. Economically speaking, Hemphill County's is largely dependent on mining and mineral extraction-related businesses and services. Hemphill County is Texas's 142nd biggest county (912 square miles). It's located in the Panhandle Texas region of the state.