South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. Land for sale in Medina County, Texas, recently totaled almost $139 million and around 100,000 acres. Medina County ranks 48th out of 254 counties in the Lone Star State for the total acreage of land currently advertised for sale. There were four properties listed as sold in Medina County through the Lands of America Comparable Sales Program. This represented a total value of $2,489,610. Of all farms and ranches for sale in Medina County, Devine featured the most land for sale. Medina County is Texas's 30th largest county (1,334 square miles). It's located in the Edwards Plateau South Texas region of Texas.