Land for sale in Refugio County, Texas, recently totaled over $25 million and over 6,500 acres. Refugio County ranks 155th out of 254 counties in Texas for the combined amount of land currently advertised for sale. Refugio County is the 200th largest county (818 square miles) in Texas. Refugio County is in the South Texas region of the state. Austwell had the most land for sale. Economically speaking, Refugio County's is largely dependent on mining and mineral extraction-related businesses and services.